After being dismissed for 100 in the first ODI on Wednesday, India had their total eclipsed within 17 overs as Australia made light work of the chase.
The result continued an up-and-down run for the tourists in recent months.
They failed to make the semi-finals of a World Cup event for the first time in eight years in October's T20 tournament, before beating New Zealand 2-1 in an ODI series.
Several of India's players have spent the past five weeks in Australia for the WBBL, with the final two ODIs of this series their last before returning home.
But Australia's players do not expect India to be merely counting down the days before their return home, ahead of Sunday's must-win match for the visitors.
"I'm sure they wouldn't be too pleased with how they went about the innings the other day," Australia's seamer Kim Garth said.
Kim Garth took 1-20 in Australia's convincing win over India in the first ODI in Brisbane. (Jono Searle/AAP PHOTOS)
"I can't imagine them coming out anything but firing tomorrow.
"They have a lot of world-class players in their line-up and I'm sure they'll come out firing.
"We have had some really good games of cricket against India over the years, the last few years in particular."
Garth was one of the causes of India's problems on Wednesday.
The Irish-born medium-pacer took 1-20 from eight overs in the series opener, while at the other end Megan Schutt ran through the Indians, taking a career-best 5-19.
"We complement each other really well, Schutter swinging the ball in and myself swinging it away," Garth said.
"It's always nice to bowl down the other end with Schutter, she's not going to miss much."
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